◎研究方向
1.微流控
2.功能聚合物-包裹與可控釋放
3.非常規采油與多孔介質智能調剖

◎指導研究生
博士生：
2022級：任玲玲，劉爽
歡迎石油工程、化工，高分子、生物，力學等相關專業背景的學生報考博士及碩士研究生

◎承擔科研課題
國家自然科學基金麵上項目，58萬，2021-2026；
國家海外高層次人才引進計劃青年項目，250萬，2021-2026；
病原體認證，美國國防高級研究計劃局，$12,117,522, 2018-2022；
智能驅替材料的合成及應用，大慶油田-金智瑞材料有限公司，$11,000，2019-2020；
基於微流控的用於降低殺蟲劑的損失，巴斯夫化學公司，$300,000，2018-2020；
超薄凝膠用於微環境的修複，美國衛生部，$665,836, 2017-2020；
液態金屬的包覆以及應用，美國德雷珀實驗室，$ 30,000，2019-2020；
智能驅替材料在三次采油的應用，美國石油能源聯盟，$1,500,000美元，2011-2016；
以液滴微流控為基礎的多層膠囊組裝的微流控裝置的製備與研究，巴斯夫化學公司， $300,000，2013-2014；

◎榮譽稱號
國家特聘青年專家

◎論文
1.Yan Zhang, Xue-Zhi Zhao, Pei-Hui Han, Li-Yuan Zhang, David A Weitz, Yu-Jun Feng, Visualization of adaptive polymer flow and displacement in medium-permeable 3D core-on-a-chip, Petroleum Science, 2022
2.Yi-Ning Wu, Li-Sha Tang, Yuan Li, Li-Yuan Zhang*, Xu Jin, Ming-Wei Zhao, Xiang Feng, Cai-Li Dai, Probing the influence of secondary fracture connectivity on fracturing fluid flowback efficiency, Petroleum Science, 2022
3.Bo Li, Xin Li, Xiaodong Chu, Pengcheng Lou, Yin Yuan, Aoxiang Zhuge, Xueling Zhu, Yangfan Shen, Jinghua Pan, Liyuan Zhang*, Lanjuan Li*, Zhongwen Wu*, Micro-ecology Restoration of Colonic Inflammation by In-Situ Oral Delivery of Antibody-laden Hydrogel Microcapsules, Bioactive Materials, 2022, 15, 305-315
4.Zhijun Li, Yizhou Jiang, Shihuan Tang, Haixia Zou, Wentao Wang, Guangpei Qi, Hongbo Zhang, Kun Jin, Yuhe Wang, Hong Chen, Liyuan Zhang*, Xiangmeng Qu*, 2D nanomaterial sensing array using machine learning for differential profiling of pathogenic microbial taxonomic identification, Microchimica Acta, 2022, 189, 1-14
5.Haoyue Zhang¶¶, Liyuan Zhang¶¶, Chuanfeng An, Yang Zhang, Fei Shao, Yijie Gao, Yonghao Zhang, Hanting Li, Yujie Zhang, Changle Ren, Kai Sun, Wei He, Fang Cheng, Huanan Wang, David A Weitz, Large-scale single-cell encapsulation in microgels through metastable droplet-templating combined with microfluidic-integration, Biofabrication, 2022, 6;14(3)
6.Xiaowan Yuan, Daiqin Xiao, Wei Yao, Zhihao Zhang, Lin Yang, Liyuan Zhang, Yibo Zeng, Jiaqi Liao, Shanxiong Luo, Chonghao Li, Hong Chen, Xiangmeng Qu, High-fidelity transfer of area-selective atomic layer deposition grown HfO2 through DNA origami-assisted nanolithography, Nano Research, 2022, 15, 5687-5694.
7.Zhijun Li, Kun Jin, Hong Chen, Liyuan Zhang*, Guitao Zhang, Yizhou Jiang, Haixia Zou, Wentao Wang, Guangpei Qi, Xiangmeng Qu*, A machine learning approach-based array sensor for rapidly predicting the mechanisms of action of antibacterial compounds, Nanoscale, 2022, 5245-5246.
8.Jienan Shen¶, Liyuan Zhang¶, Junjie Yuan, Yongsheng Zhu, Hao Cheng, Yibo Zeng, Jiaqin Wang, Xueqiu You, Chaoyong Yang, Xiangmeng Qu*, Hong Chen*, Digital Microfluidic Thermal Control Chip-Based Multichannel Immunosensor for Noninvasively Detecting Acute Myocardial Infarction, Analytical Chemistry 2021, 93, 45, 15033-15041
9.Maimaitimin Aizitiaili, Yizhou Jiang, Li Jiang, Xiaowan Yuan, Kun Jin, Hong Chen, Liyuan Zhang*, Xiangmeng Qu*, Programmable Engineering of DNA-AuNP Encoders Integrated Multimodal Coupled Analysis for Precision Discrimination of Multiple Metal Ions, Nano Letter, 2021, 21, 5, 2141-2148
10.Liyuan Zhang, Alireza Abbaspourrad, Shima Parsa, Jizhou Tang, Flavia M Cassiola, Meng Zhang, Shouceng Tian, Caili Dai, Lizhi Xiao, David A Weitz*, Core-shell Nanohydrogels with Programmable Swelling for Conformance Control in Porous Media, ACS Applied Material and Interfaces 2020, 12, 30, 34217–34225
11.Wen Li+¶, Liyuan Zhang+¶, Xuehui Ge+¶, Biyi Xu, Weixia Zhang, Liangliang Qu, Chang-Hyung Choi, Jianhong Xu, Afang Zhang, Hyomin Lee*, David A Weitz*, Microfluidic fabrication of microparticles for biomedical applications, Chemical Society Reviews, 2018, 47, 5646-5683
12.Liyuan Zhang, Chang‐Hyung Choi, Angelo S Mao, Hongbing Liao, Stefanie Utech, David J Mooney, Huanan Wang, David A Weitz, Small, 2018, 14, 1702955
13.Liyuan Zhang, Li‐Heng Cai, Philipp S Lienemann, Torsten Rossow, Ingmar Polenz, Queralt Vallmajo‐Martin, Martin Ehrbar, Hui Na, David J Mooney, David A Weitz, One‐step microfluidic fabrication of polyelectrolyte microcapsules in aqueous conditions for protein release, Angewandte Chemie International Edition, 2016, 128, 13668-13672
14.Anqi Chen, Xue-hui Ge, Jian Chen, Liyuan Zhang*, Jian-Hong Xu*, Multi-functional micromotor: microfluidic fabrication and water treatment application, Lab on a Chip, 2017, 17, 4220-4224
15.Liyuan Zhang, Duo Qi, Chengji Zhao, Hui Na, In-situ self-crosslinked sulfonated poly (arylene ether ketone) with alkyl side chain for enhanced performance, Journal of Membrane Science, 2016, 508, 15-21
16.Liyuan Zhang, Duo Qi, Gang Zhang, Chengji Zhao, Hui Na, Crosslinked tri-side-chain-type sulfonated poly (arylene ether ketones) with enhanced proton conductivity by a Friedel–Crafts acylation reaction, RSC Advances, 2014, 4, 94, 51916-51925
17.Liyuan Zhang, Gang Zhang, Chengji Zhao, Zhongguo Liu, Hao Jiang, Shuai Xu, Mingyu Li, Dan Xu, Hui Na, High proton-conducting polymer electrolytes based on pendent poly (arylene ether ketone) with H-bond for proton exchange membranes, International Journal of Hydrogen Energy, 2013, 38, 12363-12373
18.Liyuan Zhang, Gang Zhang, Chengji Zhao, Hao Jiang, Jing Wang, Dan Xu, Yang Zhang, Ke Shao, Zhongguo Liu, Wengjia Ma, Hongtao Li, Mingyu Li, Shuang Wang, Hui Na, Cross-linked tri-side chains poly (arylene ether ketone) s containing pendant alkylsulfonic acid groups for proton exchange membranes, Journal of Power Sources, 2012, 201, 142-150
19.Chuanfeng An, Weijian Liu, Yang Zhang, Bo Pang, Hui Liu, Yujie Zhang, Haoyue Zhang, Liyuan Zhang, Hongbing Liao, Changle Ren, Huanan Wang, Continuous microfluidic encapsulation of single mesenchymal stem cells using alginate microgels as injectable fillers for bone regeneration, Acta Biomaterialia, Acta Biomaterialia, 2020, 111, 181-196
20.Jizhou Tang, Bo Fan, Lizhi Xiao, Shouceng Tian, Fengshou Zhang, Liyuan Zhang, David Weitz, A New Ensemble Machine-Learning Framework for Searching Sweet Spots in Shale Reservoirs, SPE J. 2020, 26 (01): 482–497
21.Yuwei Li, Yudong Zhao, Jizhou Tang, Liyuan Zhang, Yuyang Zhou, Xiuyu Zhu, Dan Jia, Mian Chen, Rock damage evolution model of pulsating fracturing based on energy evolution theory, Energy Science & Engineering, 2020, 8, 1050-1067
22.Angelo S Mao, Berna Özkale, Nisarg J Shah, Kyle H Vining, Tiphaine Descombes, Liyuan Zhang, Christina M Tringides, Sing-Wan Wong, Jae-Won Shin, David T Scadden, David A Weitz, David J Mooney, Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation, Proceedings of the National Academy of Sciences, 2019, 116, 15392-15397
23.Jie Liu, Xiacong Zhang, Xiao Chen, Liangliang Qu, Liyuan Zhang, Wen Li, Afang Zhang, Stimuli-responsive dendronized polymeric hydrogels through Schiff-base chemistry showing remarkable topological effects, Polymer Chemistry, 2018, 9, 378-387
24.Angelo S Mao, Jae-Won Shin, Stefanie Utech, Huanan Wang, Oktay Uzun, Weiwei Li, Madeline Cooper, Yuebi Hu, Liyuan Zhang, David A Weitz, David J Mooney, Deterministic encapsulation of single cells in thin tunable microgels for niche modelling and therapeutic delivery, Nature Materials, 2017, 16, 236-243
25.Feng Kong, Hongbo Zhang, Xu Zhang, Dongfei Liu, Dong Chen, Weixia Zhang, Liyuan Zhang, Hélder A Santos, Mingtan Hai, Biodegradable photothermal and pH responsive calcium carbonate@ phospholipid@ acetalated dextran hybrid platform for advancing biomedical applications, Advanced Functional Materials, 2016, 26, 6158-6169

◎專利
1.一種微流控裝置及利用該裝置製備微凝膠的方法
2.一種基於微流控及機器學習的剩餘油賦存形態判別方法
3.一種基於微流控與人工智能的油液分析設備故障預測係統
4.一種原油快速定量表征的在線式光譜檢測係統及其方法
5.一種基於人工智能的大數據類器官圖像識別的方法
6.一種基於微流控技術高通量培養的類器官結構的製備方法
7.基於人工智能和大數據分析的藥物篩選模型的搭建方法

◎學術交流
Programmable Nanohydrogel for Flow control in Porous Media, Society of Petrophysicists and Well Log Analysts, Boston, 2018.
Drop-based Microfluidic for Cell Microenvironment Control, ACS-ICHEM meeting, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 2017.
Microfluidic for Controlling Microenvironment, Dalian University of Technology, Dalian, 2017.
Assembly Stem Cell at Single Cell Level by Microfluidic, Shanghai University, Shanghai, 2017.
Mesenchymal Stem Cell 3D Assembly in multi-compartmental micro-hydrogel, Florida A&M University and Florida State University, Tallahassee, 2015.